2111-2112
| Exceptionally Potent Antispermatogenic Compounds from 8-Halogenation of (4aRS,5SR,9bRS)-Hexahydroindeno[1,2-c]pyridines
C. Edgar Cook,
Joseph M. Jump,
Pingsheng Zhang,
John R. Stephens,
Yue-Wei Lee,
Patricia A. Fail, and
Stephanie A. Anderson
[Full Article -
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2113-2116
| Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound
Daekyu Sun,
Brian Thompson,
Brian E. Cathers,
Miguel Salazar,
Sean M. Kerwin,
John O. Trent,
Terence C. Jenkins,
Stephen Neidle, and
Laurence H. Hurley
[Full Article -
PDF] |
2117-2122
| (S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800): A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen
Sylvain Gauthier,
Brigitte Caron,
Julie Cloutier,
Yves L. Dory,
Alexandre Favre,
Denis Larouche,
Josée Mailhot,
Carl Ouellet,
Annette Schwerdtfeger,
Gilles Leblanc,
Céline Martel,
Jacques Simard,
Yves Mérand,
Alain Bélanger,
Claude Labrie, and
Fernand Labrie
[Full Article -
PDF] |
2123-2125
| (1 ,2 ,3,4)-1,2-Bis[[N-propyl-N-(4-phen- oxybenzyl)amino]carbonyl]cyclobutane- 3,4-dicarboxylic Acid (A-87049): A Novel Potent Squalene Synthase Inhibitor
Anthony K. L. Fung,
William R. Baker,
Steven Fakhoury,
Herman H. Stein,
Jerry Cohen,
Bernard G. Donner,
David S. Garvey,
Kenneth P. Spina, and
Saul H. Rosenberg
[Full Article -
PDF] |
2126-2132
| 5,6-cis-Penems: Broad-Spectrum Anti-Methicillin-Resistant Staphylococcus aureus -Lactam Antibiotics
Masaji Ishiguro,
Rie Tanaka,
Koushi Namikawa,
Takaaki Nasu,
Hidekazu Inoue,
Takashi Nakatsuka,
Yoshiaki Oyama, and
Seiichi Imajo
[Full Article -
PDF] |
2133-2139
| Discovery of Prototype Peptidomimetic Agonists at the Human Melanocortin Receptors MC1R and MC4R
Carrie Haskell-Luevano,
Siska Hendrata,
Cheryl North,
Tomi K. Sawyer,
Mac E. Hadley,
Victor J. Hruby,
Chris Dickinson, and
Ira Gantz
[Full Article -
PDF] |
2140-2147
| Further Definition of the D1 Dopamine Receptor Pharmacophore: Synthesis of trans-6,6a,7,8,9,13b-Hexahydro-5H-benzo[d]naphth[2,1-b]azepines as Rigid Analogues of -Phenyldopamine
Kitaw Negash,
David E. Nichols,
Val J. Watts, and
Richard B. Mailman
[Full Article -
PDF] |
2148-2155
| Structural Model of a Cyclic Dynorphin A Analog Bound to Dodecylphosphocholine Micelles by NMR and Restrained Molecular Dynamics
Michael R. Tessmer,
Jean-Philippe Meyer,
Victor J. Hruby, and
Deborah A. Kallick
[Full Article -
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2156-2163
| Substituted 3-(Phenylsulfonyl)-1-phenylimidazolidine-2,4-dione Derivatives as Novel Nonpeptide Inhibitors of Human Heart Chymase
Shinjiro Niwata,
Harukazu Fukami,
Motoo Sumida,
Akiko Ito,
Saki Kakutani,
Masayuki Saitoh,
Kenji Suzuki,
Masahiro Imoto,
Hiroshi Shibata,
Seiichi Imajo,
Yoshinobu Kiso,
Takaharu Tanaka,
Hiroshi Nakazato,
Takafumi Ishihara,
Shinji Takai,
Daisuke Yamamoto,
Naotaka Shiota,
Mizuo Miyazaki,
Hideki Okunishi,
Akio Kinoshita,
Hidenori Urata, and
Kikuo Arakawa
[Full Article -
PDF] |
2164-2176
| Potent HIV Protease Inhibitors Containing a Novel (Hydroxyethyl)amide Isostere
Pierre L. Beaulieu,
Dominik Wernic,
Abraham Abraham,
Paul C. Anderson,
Tibor Bogri,
Yves Bousquet,
Gilbert Croteau,
Ingrid Guse,
Daniel Lamarre,
Francine Liard,
William Paris,
Diane Thibeault,
Susan Pav, and
Liang Tong
[Full Article -
PDF] |
2177-2183
| A Facile, Alternative Synthesis of 4'-Thioarabinonucleosides and Their Biological Activities
Yuichi Yoshimura,
Mikari Watanabe,
Hiroshi Satoh,
Noriyuki Ashida,
Katsushi Ijichi,
Shinji Sakata,
Haruhiko Machida, and
Akira Matsuda
[Full Article -
PDF] |
2184-2190
| Synthesis and Cellular Uptake of 2'-Substituted Analogues of (E)-5-(2-[125I]Iodovinyl)-2'-deoxyuridine in Tumor Cells Transduced with the Herpes Simplex Type-1 Thymidine Kinase Gene. Evaluation as Probes for Monitoring Gene Therapy
Kevin W. Morin,
Elena D. Atrazheva,
Edward E. Knaus, and
Leonard I. Wiebe
[Full Article -
PDF] |
2191-2195
| Phosphodiester Amidates of Unsaturated Nucleoside Analogues: Synthesis and Anti-HIV Activity
Holger Winter,
Yosuke Maeda,
Hiroyuki Uchida,
Hiroaki Mitsuya, and
Jiri Zemlicka
[Full Article -
PDF] |
2196-2210
| Potent Tetracyclic Guanine Inhibitors of PDE1 and PDE5 Cyclic Guanosine Monophosphate Phosphodiesterases with Oral Antihypertensive Activity
Ho-Sam Ahn,
Ana Bercovici,
George Boykow,
Alan Bronnenkant,
Samuel Chackalamannil,
Jason Chow,
Renee Cleven,
John Cook,
Michael Czarniecki,
Carol Domalski,
Ahmad Fawzi,
Michael Green,
Asli Gündes,
Ginny Ho,
Malvina Laudicina,
Neil Lindo,
Ke Ma,
Mahua Manna,
Brian McKittrick,
Bita Mirzai,
Terry Nechuta,
Bernard Neustadt,
Chester Puchalski,
Kathryn Pula,
Lisa Silverman,
Elizabeth Smith,
Andrew Stamford,
Richard P. Tedesco,
Hsingan Tsai,
Deen Tulshian,
Henry Vaccaro,
Robert W. Watkins,
Xiaoyu Weng,
Joseph T. Witkowski,
Yan Xia, and
Hongtao Zhang
[Full Article - PDF] |
2211-2216
| Iron-Mediated Generation of the Neurotoxin 6-Hydroxydopamine Quinone by Reaction of Fatty Acid Hydroperoxides with Dopamine: A Possible Contributory Mechanism for Neuronal Degeneration in Parkinson's Disease
Alessandro Pezzella,
Marco d'Ischia,
Alessandra Napolitano,
Giovanna Misuraca, and
Giuseppe Prota
[Full Article - PDF] |
2217-2227
| Steroidal Affinity Labels of the Estrogen Receptor. 3. Estradiol 11-n-Alkyl Derivatives Bearing a Terminal Electrophilic Group: Antiestrogenic and Cytotoxic Properties
Carole Lobaccaro,
Jean-François Pons,
Marie-Josèphe Duchesne,
Gilles Auzou,
Michel Pons,
François Nique,
Georges Teutsch, and
Jean-Louis Borgna
[Full Article - PDF] |
2228-2240
| Design of a Potent Combined Pseudopeptide Endothelin-A/Endothelin-B Receptor Antagonist, Ac-DBhg16-Leu-Asp-Ile-[NMe]Ile-Trp21 (PD 156252): Examination of Its Pharmacokinetic and Spectral Properties
Wayne L. Cody,
John X. He,
Michael D. Reily,
Stephen J. Haleen,
Donnelle M. Walker,
Eric L. Reyner,
Barbra H. Stewart, and
Annette M. Doherty
[Full Article - PDF] |
2241-2251
| Lanthionine-Somatostatin Analogs: Synthesis, Characterization, Biological Activity, and Enzymatic Stability Studies
George Ösapay,
Laszlo Prokai,
Ho-Seung Kim,
Katalin F. Medzihradszky,
David H. Coy,
George Liapakis,
Terry Reisine,
Giuseppe Melacini,
Qin Zhu,
Susan H.-H. Wang,
Ralph-Heiko Mattern, and
Murray Goodman
[Full Article - PDF] |
2252-2258
| A Refined Model for the Somatostatin Pharmacophore: Conformational Analysis of Lanthionine-Sandostatin Analogs
Giuseppe Melacini,
Qin Zhu,
George Ösapay, and
Murray Goodman
[Full Article - PDF] |
2259-2265
| Conformational Dynamics of Thyroid Hormones by Variable Temperature Nuclear Magnetic Resonance: The Role of Side Chain Rotations and Cisoid/Transoid Interconversions
Brendan M. Duggan and
David J. Craik
[Full Article - PDF] |
2266-2275
| Antitumor Agents. 174. 2',3',4',5,6,7-Substituted 2-Phenyl-1,8-naphthyridin-4-ones: Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization
Ke Chen,
Sheng-Chu Kuo,
Ming-Chieh Hsieh,
Anthony Mauger,
Chii M. Lin,
Ernest Hamel, and
Kuo-Hsiung Lee
[Full Article - PDF] |
2276-2286
| Synthesis and Cytotoxic Evaluation of Substituted Sulfonyl-N-hydroxyguanidine Derivatives as Potential Antitumor Agents
Ji-Wang Chern,
Yu-Ling Leu,
Shan-Shue Wang,
Ruwen Jou,
Chin-Fen Lee,
Pei-Chie Tsou,
Shih-Chung Hsu,
Yen-Chywan Liaw, and
Hua-Mei Lin
[Full Article - PDF] |
2287-2287
| A Lifetime of Synergy with Theory and Experiment By Andrew Streitwieser. In Profiles, Pathways and Dreams. Series Editor Jeffrey I. Seeman. American Chemical Society, Washington, DC. 1997. xxvii + 310 pp. 15.5 × 23.5 cm. ISBN O-8412-1836-6. $24.95.
George L. Kenyon
[Full Article - PDF] |
2287-2287
| Medicinal Chemistry: Today and Tomorrow Edited by Mikio Yamazaki. Blackwell Science Ltd., Oxford. 1997. x + 278 pp. 19.5 × 28 cm. ISBN 0-632-04272-9. $99.95.
Donald T. Witiak
[Full Article - PDF] |
2288-2288
| Water Soluble Furoxan Derivatives as NO Prodrugs
Giovanni Sorba,
Claudio Medana,
Roberta Fruttero,
Clara Cena,
Antonella Di Stilo,
Ubaldina Galli, and
Alberto Gasco
[Full Article - PDF] |